Kalista vs Vayne — Bot Lane (ADC) Matchup Guide

How to win lane as Kalista against Vayne · 50.07% win rate over 1,336 Emerald+ games · Updated 2026-07-27

Verdict: Kalista is favoured — Kalista owns 6 of the 7 game windows to Vayne's 1. Kalista wins 50.07% of games vs Vayne in bot lane (adc) (1,336 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1KalistaYour ranged auto-attacks and Q outrange Vayne's melee attack window at level 1.
Level 2KalistaAt level 2 your extra ability lets you keep poking while she can only trade in her hurt range.
Level 3KalistaBy level 3 full Q-W-E lets you stack Rend faster than she can Tumble away.
Levels 4-5KalistaThrough levels 4-5 your poke and spear stacks keep her chunked and pushed off farm.
Level 6KalistaYour level 6 Fate's Call plus support CC is a stronger all-in than her stealth ult.
First itemKalistaYour first-item power spike arrives before her Guinsoo's/Botrk online.
Two+ itemsVayneWith two-plus items Vayne's true damage, resets and Condemn make her the superior late-game duelist.

Early game (levels 1–5)

You own levels 1-2: your ranged autos and Q outrange her melee attack range, so trade the instant she walks up for a caster minion and start layering Rend stacks.

Read the rest of this matchup

The full Kalista vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Playing the other side? Vayne vs Kalista guide →
All Kalista bot lane (adc) matchups →