The champions that counter Pantheon hardest in mid lane are Vex (42.72%), Malzahar (44.49%) and Hwei (44.93%) — those are Pantheon's own pooled win rates. The easiest matchups are Karma (55.98%), Mel (54.28%) and Ryze (53.65%).
46 researched matchup guides for Pantheon in mid lane, most-played first. Win rates are Pantheon's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Pantheon vs Yasuo | 52.67% | 5,059 | Leans Pantheon |
| Pantheon vs Sylas | 50% | 4,620 | Even |
| Pantheon vs Viktor | 47.66% | 4,234 | Leans Viktor |
| Pantheon vs Zed | 49.6% | 4,111 | Even |
| Pantheon vs Ahri | 46.69% | 3,975 | Leans Ahri |
| Pantheon vs Katarina | 47.68% | 3,884 | Leans Katarina |
| Pantheon vs Syndra | 46.5% | 3,824 | Leans Syndra |
| Pantheon vs Yone | 52.42% | 3,424 | Leans Pantheon |
| Pantheon vs Akali | 51% | 3,384 | Leans Pantheon |
| Pantheon vs Fizz | 49.04% | 2,965 | Leans Fizz |
| Pantheon vs Malzahar | 44.49% | 2,846 | Malzahar favoured |
| Pantheon vs Lissandra | 45.51% | 2,571 | Leans Lissandra |
| Pantheon vs Twisted Fate | 46.22% | 2,566 | Leans Twisted Fate |
| Pantheon vs Vladimir | 46.8% | 2,421 | Leans Vladimir |
| Pantheon vs Lux | 47.94% | 2,386 | Leans Lux |
| Pantheon vs Xerath | 45.34% | 2,382 | Leans Xerath |
| Pantheon vs Hwei | 44.93% | 2,281 | Hwei favoured |
| Pantheon vs Galio | 49.72% | 2,144 | Even |
| Pantheon vs Diana | 45.67% | 2,067 | Leans Diana |
| Pantheon vs LeBlanc | 48.6% | 1,926 | Leans LeBlanc |
| Pantheon vs Naafiri | 49.53% | 1,696 | Even |
| Pantheon vs Ryze | 53.65% | 1,670 | Leans Pantheon |
| Pantheon vs Vex | 42.72% | 1,620 | Vex favoured |
| Pantheon vs Mel | 54.28% | 1,601 | Leans Pantheon |
| Pantheon vs Veigar | 46.55% | 1,596 | Leans Veigar |
| Pantheon vs Ekko | 49.31% | 1,519 | Even |
| Pantheon vs Orianna | 49.41% | 1,510 | Even |
| Pantheon vs Talon | 49.96% | 1,433 | Even |
| Pantheon vs Irelia | 47.6% | 1,353 | Leans Irelia |
| Pantheon vs Akshan | 47.12% | 1,352 | Leans Akshan |
| Pantheon vs Zoe | 48.18% | 1,287 | Leans Zoe |
| Pantheon vs Qiyana | 50.22% | 1,137 | Even |
| Pantheon vs Anivia | 49.31% | 1,093 | Even |
| Pantheon vs Aurora | 50.84% | 1,064 | Leans Pantheon |
| Pantheon vs Kassadin | 53.08% | 959 | Leans Pantheon |
| Pantheon vs Karma | 55.98% | 827 | Pantheon favoured |
| Pantheon vs Ziggs | 50.12% | 814 | Even |
| Pantheon vs Aurelion Sol | 48.91% | 689 | Leans Aurelion Sol |
| Pantheon vs Taliyah | 48.09% | 680 | Leans Taliyah |
| Pantheon vs Cassiopeia | 50.61% | 658 | Even |
| Pantheon vs Swain | 50.66% | 608 | Even |
| Pantheon vs Azir | 47.39% | 574 | Leans Azir |
| Pantheon vs Brand | 47.01% | 536 | Leans Brand |
| Pantheon vs Neeko | 49.86% | 367 | Even |
| Pantheon vs Annie | 49.13% | 287 | Leans Annie |
| Pantheon vs Locke | — | — | — |