How to win lane as Cassiopeia against Vladimir · 46.53% win rate over 144 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Vlad is one of the weakest level 1s, but so are you — deny his Transfusion last-hit heals and set up the lane instead of fighting. |
| Level 2 | Cassiopeia | Your Noxious Blast into refunded Twin Fang chains a DOT he can't escape without Sanguine Pool, and Transfusion alone won't out-heal it. |
| Level 3 | Cassiopeia | Your full Q-into-Twin-Fang combo with move-speed kiting beats a Vlad who can only Transfusion and run — punish before his AP items. |
| Levels 4-5 | Cassiopeia | Petrifying Gaze plus your kite cones him before he can rotate Pool — your last clean window before his AP items come online. |
| Level 6 | Vladimir | His Sanguine Pool charge and Riftmaker/Rod of Ages sustain let him drain through your DOT and outlast you in extended trades. |
| First item | Vladimir | He Pools your R and Twin Fang on reaction now, and his item sustain undoes the poke that used to win you the lane. |
| Two+ items | Vladimir | Full-AP Vlad Pools your R and Ignite, Transfusion-drains every poison tick, and bursts you with charged E into Q while you stay squishy and short-ranged. |
Vlad is a weak level 1 just like you, so deny his Transfusion last-hits and set up rather than face-checking a fight you both lose. From level 2 your Noxious Blast into refunded Twin Fang starts to chain, and a Vlad without Sanguine Pool has no escape from your passive move-speed kite — punish him before he hits 6. Watch his Transfusion: every minion he last-hits with it heals him, so trade when it's on cooldown, not into it. Don't waste Miasma's grounding on him — he has no dash, so save the cloud for its slow and poison when you actually commit.
The full Cassiopeia vs Vladimir report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vladimir vs Cassiopeia guide →
All Cassiopeia top lane matchups →
Also played in: Mid Lane