How to win lane as Cassiopeia against Vladimir · 47.34% win rate (319 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
He pokes in bursts, you poke forever — survive the early chip and the treadmill out-grinds him.
Track: Vladimir's W — Sanguine Pool (28–16s cooldown). Untargetable dodge — bait it before you spend your kill window.
Read from Cassiopeia's seat: which stage windows this plan plays for against Vladimir.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Vlad is one of the weakest level 1s, but so are you — deny his Transfusion last-hit heals and set up the lane instead of fighting. |
| Level 2 | Even / skill | Your Noxious Blast into refunded Twin Fang chains a DOT he can't escape without Sanguine Pool, and Transfusion alone won't out-heal it. |
| Level 3 | Vladimir | Your full Q-into-Twin-Fang combo with move-speed kiting beats a Vlad who can only Transfusion and run — punish before his AP items. |
| Levels 4-5 | Vladimir | Petrifying Gaze plus your kite cones him before he can rotate Pool — your last clean window before his AP items come online. |
| Level 6 | Cassiopeia | Charged Tides of Blood plus Riftmaker/Rod of Ages sustain lets him drain through your DOT and outlast you in extended trades. |
| First item | Vladimir | He Pools your R and Twin Fang on reaction now, and his item sustain undoes the poke that used to win you the lane. |
| Two+ items | Vladimir | Full-AP Vlad Pools your R and Ignite, Transfusion-drains every poison tick, and bursts you with charged E into Q while you stay squishy and short-ranged. |
Vlad is a weak level 1 just like you, so deny his Transfusion last-hits and set up rather than face-checking a fight you both lose. From level 2 your Noxious Blast into refunded Twin Fang starts to chain, and a Vlad without Sanguine Pool has no escape from your Serpentine Grace kite — punish him before he hits 6. Transfusion is a 9s cooldown at rank 1 and heals off every minion he takes with it, so step up on the cast, not before it. Do not waste Miasma's grounding on him — he has no dash — and drop the cloud purely for its slow when you commit.
Pooled Emerald+ win rates from Cassiopeia's side, sampled July 2026.
The full Cassiopeia vs Vladimir report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Vladimir, slightly — Cassiopeia wins 47.34% of 319 games; winnable with the right plan.
Mostly — Vladimir has a small statistical edge (52.66% win rate), but execution decides this lane far more than the pick does.
No — if anything Vladimir has the slight edge (Cassiopeia wins 47.34%), though it stays close.
Cassiopeia takes Conqueror on the Precision tree with Presence of Mind, Legend: Haste and Last Stand, and Sorcery secondary (Manaflow Band and Transcendence) vs Vladimir.
Start Doran's Ring + 2 Health Potions and back for Oblivion Orb (≈800g) — cuts his healing. Build Seraph's Embrace / Liandry's Torment first, then Rylai's Crystal Scepter, with No boots — bank the gold into MR via Rookern later.
Playing the other side? Vladimir vs Cassiopeia guide →
All Cassiopeia top lane matchups →
More Cassiopeia top lane matchups: vs Tryndamere · vs Urgot · vs Vayne · vs Volibear · vs Warwick · vs Wukong
Also played in: Mid Lane