How to win lane as Cassiopeia against Vladimir · 49.53% win rate over 1,054 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Cassiopeia | Cassiopeia's poke output dominates Vladimir's weak early kit before his damage scales up |
| Level 2 | Cassiopeia | Cassiopeia continues to zone and punish him with superior early trading power |
| Level 3 | Cassiopeia | Cassiopeia's damage lead compounds as Vladimir still lacks meaningful AP scaling this early |
| Levels 4-5 | Cassiopeia | Cassiopeia holds full control of the lane heading into his Hemoplague unlock |
| Level 6 | Cassiopeia | Cassiopeia's stun-into-combo threatens a kill whenever Sanguine Pool is on cooldown |
| First item | Cassiopeia | Cassiopeia's DoT stacking begins to outrace his healing once she has a core item |
| Two+ items | Cassiopeia | Cassiopeia's sustained poison and execute damage keep outpacing his tankier late-game sustain |
Vladimir is one of the weaker early laners in the mid pool, with low base damage and a long Sanguine Pool cooldown that leaves him vulnerable to your poke. Punish him constantly with Noxious Blast and Miasma zoning, and don't be afraid to shove and roam since he can't punish your pushes without his pool up.
The full Cassiopeia vs Vladimir report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
Become a Founding Member — $1.99/month →🔒 Secure checkout · 💰 7-day money-back guarantee · ✋ Cancel anytime
Early Access price — $3.99/month for new members after launch.
Playing the other side? Vladimir vs Cassiopeia guide →
All Cassiopeia mid lane matchups →
Also played in: Top Lane