How to win lane as Cassiopeia against Vladimir · 46.55% win rate (2,161 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
He pokes in bursts, you damage in streams — close to Q range on his cooldowns and the DPS war is no contest.
Track: Vladimir's W — Sanguine Pool (28–16s cooldown). Untargetable dodge — bait it before you spend your kill window.
Read from Cassiopeia's seat: which stage windows this plan plays for against Vladimir.
This is Cassiopeia's own plan; across 2,161 pooled games the lane is leaning Vladimir.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Cassiopeia | Cassiopeia's poke output dominates Vladimir's weak early kit before his damage scales up |
| Level 2 | Cassiopeia | Cassiopeia continues to zone and punish him with superior early trading power |
| Level 3 | Even / skill | Cassiopeia's damage lead compounds as Vladimir still lacks meaningful AP scaling this early |
| Levels 4-5 | Even / skill | Cassiopeia holds full control of the lane heading into his Hemoplague unlock |
| Level 6 | Even / skill | Cassiopeia's stun-into-combo threatens a kill whenever Sanguine Pool is on cooldown |
| First item | Even / skill | Cassiopeia's DoT stacking begins to outrace his healing once she has a core item |
| Two+ items | Even / skill | Cassiopeia's sustained poison and execute damage keep outpacing his tankier late-game sustain |
Vladimir is one of the weaker early laners in the mid pool, with low base damage and a long Sanguine Pool cooldown that leaves him vulnerable to your poke. Punish him constantly with Noxious Blast and Miasma zoning, and don't be afraid to shove and roam since he can't punish your pushes without his pool up. Track Sanguine Pool is 28s at rank 1 and 16s at rank 5, and buys only 2 seconds of untargetability — bait it, then spend your window while it recharges.
Pooled Emerald+ win rates from Cassiopeia's side, sampled July 2026.
The full Cassiopeia vs Vladimir report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Vladimir, slightly — Cassiopeia wins 46.55% of 2,161 games; winnable with the right plan.
Mostly — Vladimir has a small statistical edge (53.45% win rate), but execution decides this lane far more than the pick does.
No — if anything Vladimir has the slight edge (Cassiopeia wins 46.55%), though it stays close.
Cassiopeia takes Conqueror on the Precision tree with Presence of Mind, Legend: Haste and Last Stand, and Sorcery secondary (Manaflow Band and Transcendence) vs Vladimir.
Start Doran's Ring + 2 Health Potions and back for Oblivion Orb (≈800g) — cuts his sustain. Build Seraph's Embrace first, then Liandry's Torment, with No boots — passive move speed (slot goes to Mercury's-substitute MR if needed).
Playing the other side? Vladimir vs Cassiopeia guide →
All Cassiopeia mid lane matchups →
More Cassiopeia mid lane matchups: vs Veigar · vs Vex · vs Viktor · vs Xerath · vs Yasuo · vs Yone
Also played in: Top Lane