How to win lane as Cassiopeia against Annie · 43.19% win rate over 257 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | Annie's passive stun timing is a pure mechanical skill check neither side inherently wins |
| Level 2 | Even / skill | Same stun-tracking skill dynamic continues to define every trade in this window |
| Level 3 | Even / skill | Stun dodging or landing keeps deciding fights evenly through this stretch |
| Levels 4-5 | Cassiopeia | Cassiopeia's item spike starts punishing Annie for over-extending stun offensively |
| Level 6 | Even / skill | Tibbers-enabled all-ins remain a coinflip skill check even with Cassiopeia's slight lead |
| First item | Cassiopeia | Cassiopeia's completed item lets her outtrade Annie once the stun threat is neutralized |
| Two+ items | Cassiopeia | Cassiopeia's sustained ranged DPS clearly outscales Annie's burst-only kit late game |
This lane is a pure skill matchup through level 5 — Annie's stun timing dictates every trade, and if she catches you with an unexpected 4-stack proc she can burst you down before you get a Twin Fang stack going. Careful stun-tracking and poking from max range with Noxious Blast is how you survive to your power spike.
The full Cassiopeia vs Annie report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Annie vs Cassiopeia guide →
All Cassiopeia mid lane matchups →