How to win lane as Cassiopeia against Warwick · 61.97% win rate over 71 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | You have one ability and no poison stacked, same as his weak level 1 before Blood Hunt is online — just last-hit at Q range and don't throw a lone Q he can walk through to trade back on you. |
| Level 2 | Cassiopeia | With Q+E online you prime poison and chain Twin Fang every time he steps to farm — the CD refund gives you DPS his early drain can't out-sustain while you stay healthy. |
| Level 3 | Cassiopeia | Your leveling Serpentine Grace move speed plus a full Q-to-E combo kites him; Miasma grounds his Infinite Duress leap, his only gap-close, so he can't stick while poison ticks. |
| Levels 4-5 | Cassiopeia | Ranks in Q and E let you chain near-continuous Twin Fangs — a grounded Warwick with no dash on his basics loses every extended trade to your sustained damage. |
| Level 6 | Cassiopeia | Petrifying Gaze cancels Infinite Duress if you stun him as he leaps in — face the dash and pre-empt it before the suppress locks you, then Twin Fang him down instead of letting the channel heal him. |
| First item | Cassiopeia | Malignance or early Liandry's plus boots-free Serpentine Grace move speed make you a kiting DPS nightmare — your ramping poison out-damages his Blood Hunt drain heals. |
| Two+ items | Cassiopeia | You stay ahead in the straight duel — Miasma grounds his R leap, Petrifying Gaze cancels it on the dash, and your poison out-races his sustain; only a fog-flank Duress that locks you first flips it. |
Warwick wants a sustained fight and you are built to win exactly that — but level 1 you have only one ability and no poison stacking, so don't throw a lone Q he can walk through and then auto you while Blood Hunt isn't even online yet. From level 2 prime with Noxious Blast (Q) and immediately Twin Fang (E) — the refunded cooldown off the poison lets you fire E again almost instantly, and his passive heal only ramps on low targets, so as long as you stay healthy your DPS out-paces his sustain. Save Miasma (W) for the moment he commits — it grounds his Infinite Duress leap and the slow keeps him parked in your poison.
The full Cassiopeia vs Warwick report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
Become a Founding Member — $1.99/month →🔒 Secure checkout · 💰 7-day money-back guarantee · ✋ Cancel anytime
Early Access price — $3.99/month for new members after launch.
Playing the other side? Warwick vs Cassiopeia guide →
All Cassiopeia top lane matchups →