The champions that counter Seraphine hardest in support are Zilean (47.53%), Poppy (49.04%) and Senna (49.28%) — those are Seraphine's own pooled win rates. The easiest matchups are Swain (55.64%), Alistar (53.73%) and Rakan (52.95%).
35 researched matchup guides for Seraphine in support, most-played first. Win rates are Seraphine's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Seraphine vs Thresh | 51.2% | 37,292 | Leans Seraphine |
| Seraphine vs Nautilus | 52.02% | 28,226 | Leans Seraphine |
| Seraphine vs Lulu | 52.19% | 28,016 | Leans Seraphine |
| Seraphine vs Nami | 51.13% | 26,886 | Leans Seraphine |
| Seraphine vs Senna | 49.28% | 25,325 | Even |
| Seraphine vs Milio | 50.4% | 23,281 | Even |
| Seraphine vs Karma | 51.84% | 23,161 | Leans Seraphine |
| Seraphine vs Lux | 51.63% | 22,675 | Leans Seraphine |
| Seraphine vs Pyke | 49.82% | 18,532 | Even |
| Seraphine vs Leona | 50.4% | 18,224 | Even |
| Seraphine vs Bard | 51.4% | 16,972 | Leans Seraphine |
| Seraphine vs Blitzcrank | 50.03% | 16,389 | Even |
| Seraphine vs Soraka | 51.85% | 14,620 | Leans Seraphine |
| Seraphine vs Yuumi | 51% | 14,147 | Leans Seraphine |
| Seraphine vs Vel'Koz | 50.19% | 12,354 | Even |
| Seraphine vs Morgana | 51.65% | 11,498 | Leans Seraphine |
| Seraphine vs Xerath | 50.32% | 11,258 | Even |
| Seraphine vs Braum | 51.71% | 10,647 | Leans Seraphine |
| Seraphine vs Sona | 50.64% | 10,512 | Even |
| Seraphine vs Janna | 50.02% | 9,906 | Even |
| Seraphine vs Zilean | 47.53% | 9,719 | Leans Zilean |
| Seraphine vs Zyra | 51.01% | 8,948 | Leans Seraphine |
| Seraphine vs Rell | 51.74% | 8,650 | Leans Seraphine |
| Seraphine vs Rakan | 52.95% | 8,644 | Leans Seraphine |
| Seraphine vs Alistar | 53.73% | 8,036 | Leans Seraphine |
| Seraphine vs Brand | 52.18% | 7,541 | Leans Seraphine |
| Seraphine vs Swain | 55.64% | 7,098 | Seraphine favoured |
| Seraphine vs Tahm Kench | 51.06% | 7,092 | Leans Seraphine |
| Seraphine vs Hwei | 52.76% | 7,008 | Leans Seraphine |
| Seraphine vs Galio | 52.16% | 6,821 | Leans Seraphine |
| Seraphine vs Neeko | 51.57% | 4,840 | Leans Seraphine |
| Seraphine vs Poppy | 49.04% | 4,254 | Leans Poppy |
| Seraphine vs Maokai | 51.59% | 3,979 | Leans Seraphine |
| Seraphine vs Renata Glasc | 51.98% | 2,872 | Leans Seraphine |
| Seraphine vs Taric | 51.12% | 2,862 | Leans Seraphine |