How to win lane as Seraphine against Karma · 53.22% win rate over 11,662 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Karma | Karma-favoured at 1 because her Mantra-Q burst out-pokes your early casts. |
| Level 2 | Karma | Karma-favoured at 2 as her Q+W root trade beats your two-cast spike. |
| Level 3 | Karma | Karma-favoured at 3 with continued Mantra poke keeping you off farm. |
| Levels 4-5 | Karma | Karma-favoured at 4-5 since her root setup and poke keep pressuring your ADC. |
| Level 6 | Even / skill | Even at 6 once your Encore matches her long-standing Mantra tempo. |
| First item | Even / skill | Even at first item as your poke and sustain trade evenly with her Mantra-Q. |
| Two+ items | Seraphine | Seraphine-favoured at 2+ items where Encore AoE charm outscales her utility ult. |
Levels 1-4 belong to Karma: her Mantra-empowered Q poke and W root out-trade your Q+E, so play safe, keep your shield for her all-in, and give up a little farm rather than eat her burst.
The full Seraphine vs Karma report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Karma vs Seraphine guide →
All Seraphine support matchups →