The champions that counter Twisted Fate hardest in mid lane are Fizz (48.31%), Sylas (48.43%) and Yasuo (48.89%) — those are Twisted Fate's own pooled win rates. The easiest matchups are Azir (57.62%), Akali (54.25%) and Karma (54.23%).
46 researched matchup guides for Twisted Fate in mid lane, most-played first. Win rates are Twisted Fate's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Twisted Fate vs Viktor | 51.18% | 13,781 | Leans Twisted Fate |
| Twisted Fate vs Sylas | 48.43% | 13,709 | Leans Sylas |
| Twisted Fate vs Ahri | 49.12% | 11,102 | Leans Ahri |
| Twisted Fate vs Syndra | 49.63% | 9,809 | Even |
| Twisted Fate vs Malzahar | 50.5% | 8,876 | Even |
| Twisted Fate vs Yone | 53.17% | 8,537 | Leans Twisted Fate |
| Twisted Fate vs Akali | 54.25% | 8,274 | Leans Twisted Fate |
| Twisted Fate vs Zed | 50.64% | 8,110 | Even |
| Twisted Fate vs Yasuo | 48.89% | 8,051 | Leans Yasuo |
| Twisted Fate vs Katarina | 50.87% | 7,484 | Leans Twisted Fate |
| Twisted Fate vs Lux | 52.38% | 6,656 | Leans Twisted Fate |
| Twisted Fate vs Xerath | 50.08% | 6,609 | Even |
| Twisted Fate vs Fizz | 48.31% | 6,381 | Leans Fizz |
| Twisted Fate vs Lissandra | 50.2% | 5,851 | Even |
| Twisted Fate vs Hwei | 50.26% | 5,762 | Even |
| Twisted Fate vs Galio | 52.8% | 5,704 | Leans Twisted Fate |
| Twisted Fate vs Naafiri | 49.75% | 5,687 | Even |
| Twisted Fate vs LeBlanc | 52.62% | 5,233 | Leans Twisted Fate |
| Twisted Fate vs Ryze | 52.91% | 5,101 | Leans Twisted Fate |
| Twisted Fate vs Karma | 54.23% | 4,935 | Leans Twisted Fate |
| Twisted Fate vs Vladimir | 48.98% | 4,647 | Leans Vladimir |
| Twisted Fate vs Talon | 51.81% | 4,489 | Leans Twisted Fate |
| Twisted Fate vs Mel | 52.74% | 4,484 | Leans Twisted Fate |
| Twisted Fate vs Diana | 50.2% | 4,480 | Even |
| Twisted Fate vs Orianna | 51.64% | 3,805 | Leans Twisted Fate |
| Twisted Fate vs Irelia | 50.87% | 3,770 | Leans Twisted Fate |
| Twisted Fate vs Veigar | 49.32% | 3,700 | Even |
| Twisted Fate vs Akshan | 51.56% | 3,658 | Leans Twisted Fate |
| Twisted Fate vs Zoe | 52.33% | 3,648 | Leans Twisted Fate |
| Twisted Fate vs Ekko | 50.93% | 3,503 | Leans Twisted Fate |
| Twisted Fate vs Ziggs | 50.38% | 3,422 | Even |
| Twisted Fate vs Vex | 52.05% | 3,099 | Leans Twisted Fate |
| Twisted Fate vs Aurora | 51.55% | 3,044 | Leans Twisted Fate |
| Twisted Fate vs Anivia | 50.15% | 3,033 | Even |
| Twisted Fate vs Qiyana | 53.87% | 3,026 | Leans Twisted Fate |
| Twisted Fate vs Kassadin | 50.29% | 2,943 | Even |
| Twisted Fate vs Pantheon | 53.78% | 2,566 | Leans Twisted Fate |
| Twisted Fate vs Annie | 49.1% | 2,432 | Leans Annie |
| Twisted Fate vs Brand | 51.4% | 2,140 | Leans Twisted Fate |
| Twisted Fate vs Taliyah | 52.43% | 2,056 | Leans Twisted Fate |
| Twisted Fate vs Swain | 51.12% | 2,009 | Leans Twisted Fate |
| Twisted Fate vs Aurelion Sol | 52.03% | 1,799 | Leans Twisted Fate |
| Twisted Fate vs Azir | 57.62% | 1,713 | Twisted Fate favoured |
| Twisted Fate vs Cassiopeia | 54.1% | 1,623 | Leans Twisted Fate |
| Twisted Fate vs Neeko | 52.38% | 1,361 | Leans Twisted Fate |
| Twisted Fate vs Locke | — | — | — |