The champions that counter Ryze hardest in mid lane are Malzahar (42.6%), Diana (43.11%) and Annie (43.27%) — those are Ryze's own pooled win rates. The easiest matchups are Orianna (51.58%), Azir (50.33%) and Akali (50.2%).
46 researched matchup guides for Ryze in mid lane, most-played first. Win rates are Ryze's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Ryze vs Sylas | 49.51% | 8,179 | Even |
| Ryze vs Viktor | 46.13% | 8,101 | Leans Viktor |
| Ryze vs Syndra | 43.72% | 6,718 | Syndra favoured |
| Ryze vs Ahri | 45.35% | 6,095 | Leans Ahri |
| Ryze vs Yone | 48.03% | 5,582 | Leans Yone |
| Ryze vs Yasuo | 48.7% | 5,371 | Leans Yasuo |
| Ryze vs Zed | 46.86% | 5,199 | Leans Zed |
| Ryze vs Twisted Fate | 47.09% | 5,101 | Leans Twisted Fate |
| Ryze vs Malzahar | 42.6% | 4,531 | Malzahar favoured |
| Ryze vs Katarina | 47.84% | 4,198 | Leans Katarina |
| Ryze vs Naafiri | 45.14% | 4,023 | Leans Naafiri |
| Ryze vs Akali | 50.2% | 3,966 | Even |
| Ryze vs Vladimir | 47.33% | 3,839 | Leans Vladimir |
| Ryze vs Lux | 48.13% | 3,665 | Leans Lux |
| Ryze vs Hwei | 44.33% | 3,623 | Hwei favoured |
| Ryze vs Lissandra | 48.24% | 3,333 | Leans Lissandra |
| Ryze vs Fizz | 48.52% | 3,256 | Leans Fizz |
| Ryze vs Xerath | 45.09% | 2,983 | Leans Xerath |
| Ryze vs Galio | 49.34% | 2,955 | Even |
| Ryze vs Karma | 50.19% | 2,943 | Even |
| Ryze vs LeBlanc | 46.83% | 2,823 | Leans LeBlanc |
| Ryze vs Diana | 43.11% | 2,774 | Diana favoured |
| Ryze vs Anivia | 45.84% | 2,727 | Leans Anivia |
| Ryze vs Orianna | 51.58% | 2,654 | Leans Ryze |
| Ryze vs Irelia | 47.74% | 2,635 | Leans Irelia |
| Ryze vs Veigar | 44.49% | 2,531 | Veigar favoured |
| Ryze vs Talon | 45.65% | 2,462 | Leans Talon |
| Ryze vs Mel | 49.85% | 2,387 | Even |
| Ryze vs Ekko | 46.3% | 2,302 | Leans Ekko |
| Ryze vs Akshan | 47.93% | 2,128 | Leans Akshan |
| Ryze vs Cassiopeia | 48.15% | 2,087 | Leans Cassiopeia |
| Ryze vs Ziggs | 47.68% | 1,837 | Leans Ziggs |
| Ryze vs Aurora | 49.95% | 1,784 | Even |
| Ryze vs Zoe | 46.46% | 1,778 | Leans Zoe |
| Ryze vs Kassadin | 49.27% | 1,768 | Even |
| Ryze vs Qiyana | 47.5% | 1,724 | Leans Qiyana |
| Ryze vs Pantheon | 46.35% | 1,670 | Leans Pantheon |
| Ryze vs Annie | 43.27% | 1,643 | Annie favoured |
| Ryze vs Vex | 47.5% | 1,596 | Leans Vex |
| Ryze vs Brand | 46.85% | 1,287 | Leans Brand |
| Ryze vs Taliyah | 46.58% | 1,269 | Leans Taliyah |
| Ryze vs Swain | 50.15% | 1,268 | Even |
| Ryze vs Aurelion Sol | 45.39% | 1,150 | Leans Aurelion Sol |
| Ryze vs Azir | 50.33% | 1,055 | Even |
| Ryze vs Neeko | 47.18% | 816 | Leans Neeko |
| Ryze vs Locke | — | — | — |