Vladimir vs Syndra — Mid Lane Matchup Guide

How to win lane as Vladimir against Syndra · 51.51% win rate over 4,399 Emerald+ games · Updated 2026-07-27

Verdict: Vladimir is favoured — Vladimir owns 4 of the 7 game windows to Syndra's 3. Vladimir wins 51.51% of games vs Syndra in mid lane (4,399 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1SyndraSyndra's Dark Sphere outranges Transfusion and pokes you at level 1.
Level 2SyndraAt 2 her Scatter the Weak stun setup punishes every trade you try.
Level 3SyndraLevel 3 her sphere-stun poke chunks you faster than you heal.
Levels 4-5VladimirBy 4-5 your Tides of Blood sustain outheals her poke output.
Level 6VladimirLevel 6 you Pool her Unleashed Power cast and win the follow-up.
First itemVladimirYour first item's drain out-sustains her poke in extended trades.
Two+ itemsVladimirAt two items your drain-tank bulk and Hemoplague outscale Syndra.

Early game (levels 1–5)

Syndra controls levels 1-3: Dark Sphere outranges your Transfusion and her stun setup punishes any step-up, so farm at max range and don't feed her sphere-stun poke.

Read the rest of this matchup

The full Vladimir vs Syndra report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Syndra vs Vladimir guide →
All Vladimir mid lane matchups →