Locke vs Vayne — Top Lane Matchup Guide

How to win lane as Locke against Vayne · 49.31% win rate over 1,156 Emerald+ games · Updated 2026-07-27

Verdict: Vayne is favoured — Vayne owns 7 of the 7 game windows. Play it patient and win your windows. Locke wins 49.31% of games vs Vayne in top lane (1,156 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1VayneTumble spacing and W true damage beat your level-1 trades.
Level 2VayneSilver Bolts shred through your grey health at level 2.
Level 3VayneCondemn wall-stun punishes your level-3 E gap-close.
Levels 4-5VayneHer kiting and true-damage scaling keep her ahead through 4-5.
Level 6VayneFinal Hour stealth dodges your Purgatory commit at 6.
First itemVaynePost-item her W bolts out-damage your single burst.
Two+ itemsVayneLate, percent-HP true damage and R stealth beat your whole kit.

Early game (levels 1–5)

Vayne out-spaces you from level 1. Tumble keeps her outside your Q-nail range, and Silver Bolts' third-hit true damage cuts through the grey health your W grants, so you take net-negative trades even when you land nails. Never E onto her near a wall or Condemn stuns and executes you. Farm safe, dodge her repositioning, and don't feed her early kills that snowball her scaling.

Read the rest of this matchup

The full Locke vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Playing the other side? Vayne vs Locke guide →
All Locke top lane matchups →