How to win lane as Kassadin against Vayne · 62.16% win rate over 37 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | Vayne tumbles (Q) and autos you down at range while your only tool is Null Sphere and you have zero gap-closer until 6. |
| Level 2 | Kassadin | Maxed Null Sphere plus Nether Blade mana lets you weather her poke and survive to your spike — she still can't kill you under tower. |
| Level 3 | Even / skill | It is roughly even on farm — neither of you wins a real all-in yet, so trade nothing and stack for level 6. |
| Levels 4-5 | Kassadin | Riftwalk gives you the gap-closer she has feared all lane — blink in, Null Sphere to silence the tumble, and burst her squishy frame. |
| Level 6 | Kassadin | Nether Blade refunds and Catalyst/Rod mana let you chase-blink twice and reset onto her — this is your hardest all-in window, so force every fight. |
| First item | Kassadin | She has no defensive layer at 6 — one caught Vayne dies before Silver Bolts can stack, so abuse the lead before her items land. |
| Two+ items | Vayne | At 2+ items her Silver Bolts true damage ignores Void Stone and condemn (E) into a wall catches you mid-Riftwalk — she reclaims the duel, so flank, don't face-tank. |
Levels 1-3 are genuinely Vayne's — she tumbles (Q) back and chips you with autos while your only tool is Null Sphere and you have no way to reach her until 6. Do not throw Q to poke: it is mana-hungry, short-ranged, and being low with no escape just feeds her. Last-hit at max range, accept the minimal chip, and stack your wave to set up a level-6 dive. Note her W Silver Bolts is percent-max-HP true damage, so building HP or trading HP early is losing math against her — the plan is purely to survive to your spike.
The full Kassadin vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vayne vs Kassadin guide →
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