The champions that counter Kassadin hardest in mid lane are Zed (45.74%), Talon (45.96%) and Pantheon (46.92%) — those are Kassadin's own pooled win rates. The easiest matchups are Mel (56.82%), Orianna (54.88%) and Annie (53.37%).
46 researched matchup guides for Kassadin in mid lane, most-played first. Win rates are Kassadin's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Kassadin vs Viktor | 51.45% | 6,041 | Leans Kassadin |
| Kassadin vs Ahri | 50.99% | 6,015 | Leans Kassadin |
| Kassadin vs Yasuo | 51.92% | 5,531 | Leans Kassadin |
| Kassadin vs Sylas | 49.19% | 5,515 | Leans Sylas |
| Kassadin vs Yone | 48.69% | 5,514 | Leans Yone |
| Kassadin vs Katarina | 50.97% | 5,409 | Leans Kassadin |
| Kassadin vs Syndra | 49.31% | 4,976 | Even |
| Kassadin vs Malzahar | 49.87% | 4,004 | Even |
| Kassadin vs Vladimir | 49.62% | 3,980 | Even |
| Kassadin vs Fizz | 52.49% | 3,898 | Leans Kassadin |
| Kassadin vs Zed | 45.74% | 3,631 | Leans Zed |
| Kassadin vs Lux | 52.27% | 3,553 | Leans Kassadin |
| Kassadin vs Naafiri | 50.42% | 3,215 | Even |
| Kassadin vs Lissandra | 50.1% | 3,120 | Even |
| Kassadin vs Akali | 52.9% | 3,017 | Leans Kassadin |
| Kassadin vs Twisted Fate | 49.71% | 2,943 | Even |
| Kassadin vs Xerath | 49.51% | 2,755 | Even |
| Kassadin vs Hwei | 48.58% | 2,709 | Leans Hwei |
| Kassadin vs Talon | 45.96% | 2,687 | Leans Talon |
| Kassadin vs LeBlanc | 52.41% | 2,675 | Leans Kassadin |
| Kassadin vs Veigar | 50.31% | 2,634 | Even |
| Kassadin vs Diana | 50.4% | 2,631 | Even |
| Kassadin vs Karma | 52.89% | 2,488 | Leans Kassadin |
| Kassadin vs Ekko | 50.75% | 2,485 | Leans Kassadin |
| Kassadin vs Irelia | 51.35% | 2,302 | Leans Kassadin |
| Kassadin vs Akshan | 47.69% | 2,055 | Leans Akshan |
| Kassadin vs Galio | 49.13% | 2,019 | Leans Galio |
| Kassadin vs Zoe | 52.29% | 1,945 | Leans Kassadin |
| Kassadin vs Mel | 56.82% | 1,781 | Kassadin favoured |
| Kassadin vs Ryze | 50.73% | 1,768 | Even |
| Kassadin vs Qiyana | 53.23% | 1,642 | Leans Kassadin |
| Kassadin vs Anivia | 49.04% | 1,568 | Leans Anivia |
| Kassadin vs Orianna | 54.88% | 1,547 | Leans Kassadin |
| Kassadin vs Aurora | 52.79% | 1,502 | Leans Kassadin |
| Kassadin vs Vex | 48.92% | 1,490 | Leans Vex |
| Kassadin vs Brand | 49.52% | 1,244 | Even |
| Kassadin vs Annie | 53.37% | 1,128 | Leans Kassadin |
| Kassadin vs Swain | 50.63% | 1,108 | Even |
| Kassadin vs Ziggs | 52.68% | 1,101 | Leans Kassadin |
| Kassadin vs Aurelion Sol | 53.03% | 1,005 | Leans Kassadin |
| Kassadin vs Pantheon | 46.92% | 959 | Leans Pantheon |
| Kassadin vs Cassiopeia | 51.83% | 793 | Leans Kassadin |
| Kassadin vs Taliyah | 49.49% | 782 | Even |
| Kassadin vs Azir | 52.69% | 744 | Leans Kassadin |
| Kassadin vs Neeko | 53.23% | 635 | Leans Kassadin |
| Kassadin vs Locke | — | — | — |