How to win lane as Warwick against Vayne · 50.55% win rate over 813 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | Vayne's Condemn and Tumble spacing beat your short-range trades from level 1. |
| Level 2 | Vayne | Level 2 stays hers as Condemn threatens to stun you out of every commit. |
| Level 3 | Vayne | Level 3 favors Vayne because Tumble re-spacing denies your Q Jaws engage. |
| Levels 4-5 | Vayne | Levels 4-5 remain hers as her kite tools out-trade your dash-in. |
| Level 6 | Even / skill | Level 5 is a brief skill window where your peak all-in can catch a mispositioned Vayne. |
| First item | Vayne | At 6 Final Hour stealth and Silver Bolts let her escape your R and out-DPS you. |
| Two+ items | Vayne | With two-plus items her true-damage hyper-carry scaling and kiting keep the matchup hers. |
Vayne wins the early lane: Condemn knocks you out of your Q Jaws range or stuns you into a wall, and Tumble constantly re-spaces so you never get a clean trade. Don't dash in blindly, force her to waste E on a fake commit, and just farm safely while you're the weaker champ.
The full Warwick vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vayne vs Warwick guide →
All Warwick top lane matchups →