Illaoi vs Vayne — Top Lane Matchup Guide

How to win lane as Illaoi against Vayne · 53.76% win rate (1,395 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15

Verdict: Illaoi is slightly favoured — 53.76% win rate over 1,395 games, and Illaoi's game plan below claims 5 of the 7 stage windows.

At a glance

She kites your field — E her to stick, all-in early before she scales.

Track: Vayne's E — Condemn (20–12s cooldown). Wall-stun. Position so she can’t pin you.

Do

E her to stick
All-in early before she scales
Build resists, not raw HP

Don't

Get condemned from your field
Chase her tumbles blindly
Let her free-farm to 2 items

Runes & build vs Vayne

Start: Doran's Shield + Health Potion (vs her poke)
First back: Core component + boots (≈1300g)
First item: Iceborn Gauntlet (the slow makes tentacles land)
Then: Sterak's Gage
Boots: Plated Steelcaps
Runes: Grasp of the Undying (Resolve): Demolish, Second Wind, Overgrowth · Precision: Triumph, Legend: Haste · Shards: Health Scaling, Adaptive Force, Health

Favour timeline — the windows in Illaoi's game plan

Read from Illaoi's seat: which stage windows this plan plays for against Vayne.

Stage	Favoured	Why
Level 1	Vayne	Vayne's Silver Bolts true damage and Tumble spacing win L1 harass.
Level 2	Illaoi	At L2 your E reaches 900; her Condemn answer only reaches 550.
Level 3	Illaoi	At L3 a tethered Vayne can't escape your W-into-tentacle burst.
Levels 4-5	Illaoi	Levels 4-5 stay yours as she has no answer to E once locked.
Level 6	Illaoi	Leap of Faith on a tethered Vayne is a guaranteed kill at 6.
First item	Illaoi	With your first item you still win any fight that starts on your E.
Two+ items	Vayne	Late her Silver Bolts %max-HP true damage shreds the HP you stacked.

How to beat Vayne as Illaoi: the early game

Vayne edges L1: Silver Bolts (W) costs nothing and its third hit is %max-HP true damage, and Tumble (Q) spaces your Q. Take the chip, farm the wave, and wait for level 2.

Hardest and easiest matchups for Illaoi in top lane

Pooled Emerald+ win rates from Illaoi's side, sampled July 2026.

Hardest

Illaoi vs Master Yi — 44.44% win rate
Illaoi vs Singed — 44.95% win rate
Illaoi vs Garen — 45.12% win rate

Easiest

Illaoi vs Renekton — 58.53% win rate
Illaoi vs Quinn — 56.29% win rate
Illaoi vs Swain — 55.99% win rate

Read the rest of this matchup

The full Illaoi vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Common questions

Who wins Illaoi vs Vayne in top lane?

Illaoi, slightly — a 53.76% win rate edge over 1,395 games; execution can flip it.

Is Illaoi vs Vayne a skill matchup?

Mostly — Illaoi has a small statistical edge (53.76% win rate), but execution decides this lane far more than the pick does.

Does Illaoi counter Vayne?

Not a hard counter — Illaoi has a slight edge (53.76% win rate), and play quality decides the rest.

What runes does Illaoi take vs Vayne?

Illaoi takes Grasp of the Undying on the Resolve tree with Demolish, Second Wind and Overgrowth, and Precision secondary (Triumph and Legend: Haste) vs Vayne.

What should Illaoi build vs Vayne?

Start Doran's Shield + Health Potion (vs her poke) and back for Core component + boots (≈1300g). Build Iceborn Gauntlet (the slow makes tentacles land) first, then Sterak's Gage, with Plated Steelcaps.

More Illaoi top lane matchups: vs Trundle · vs Tryndamere · vs Urgot · vs Vladimir · vs Volibear · vs Warwick