How to win lane as Camille against Vayne · 47.19% win rate over 693 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Vayne | Vayne kites you at Level 1 with autos and Q tumble while you have a single ability and no all-in — eat minimal poke and last-hit. |
| Level 2 | Camille | Your Precision Protocol re-cast comes online at 2 — E in and Q-Q her down before condemn and a stacked Silver Bolt are real, your first kill window. |
| Level 3 | Camille | Q true damage plus a point in Tactical Sweep wins the short trade her ranged poke relies on — she can't out-DPS your burst pre-items. |
| Levels 4-5 | Camille | You out-trade a pre-item Vayne and your passive shield plus W self-heal sustain through her autos — force all-ins on her condemn cooldown. |
| Level 6 | Camille | Hextech Ultimatum locks her in an arena she cannot tumble, condemn, or kite out of — your hardest and most reliable kill on her all game. |
| First item | Even / skill | Your first-item bruiser spike roughly trades with her first item — a coin-flip window, so snowball now because it tips to her next item. |
| Two+ items | Vayne | She out-scales hard: Silver Bolts' percent-HP true damage and condemn kiting shred you at full build — play for picks and let your team isolate her. |
Level 1 is hers — you have one ability and no all-in while she kites you with autos and Q tumble, and you eat free percent-HP true poke from her third Silver Bolt if you walk up. Hold your ground, last-hit, and wait. At Level 2 your Precision Protocol re-cast (the second hit adds true damage and a brief move-speed pop) comes online and the lane flips: E in, Q twice, and burn her health bar before condemn and a stacked Silver Bolt are real threats. Your passive shield absorbs her first auto, so trade through it and bait the condemn — once her E is down you can dive freely.
The full Camille vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Vayne vs Camille guide →
All Camille top lane matchups →