How to win lane as Camille against Vayne · 47.95% win rate (1,001 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
Her condemn and %-true kite your hookshot — she stays out of range all game. Build armor and gank-pressure her.
Track: Vayne's E — Condemn (20–12s cooldown). Wall-stun. E-stun her so she can’t kite.
Read from Camille's seat: which stage windows this plan plays for against Vayne.
This is Camille's own plan; across 1,001 pooled games the lane is leaning Vayne.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Camille | Vayne kites you at Level 1 with autos and Q tumble while you have a single ability and no all-in — eat minimal poke and last-hit. |
| Level 2 | Camille | Your Precision Protocol re-cast comes online at 2 — E in and Q-Q her down before condemn and a stacked Silver Bolt are real, your first kill window. |
| Level 3 | Camille | Q true damage plus a point in Tactical Sweep wins the short trade her ranged poke relies on — she can't out-DPS your burst pre-items. |
| Levels 4-5 | Even / skill | You out-trade a pre-item Vayne and Adaptive Defenses plus the W self-heal sustain through her autos — all-in inside Condemn's 20s. |
| Level 6 | Camille | The Hextech Ultimatum locks her in an arena Tumble and Condemn cannot answer — just open it while her 100s Final Hour is spent. |
| First item | Even / skill | Your first-item bruiser spike roughly trades with her first item — a coin-flip window, so snowball now because it tips to her next item. |
| Two+ items | Vayne | She out-scales hard: Silver Bolts' percent-HP true damage and condemn kiting shred you at full build — play for picks and let your team isolate her. |
Level 1 is hers — you have one ability and no all-in while she kites you with autos and Tumble, and the third Silver Bolts hit adds true damage if you walk up. Hold your ground, last-hit, and wait. At Level 2 your Precision Protocol re-cast (the second hit adds true damage and a brief move-speed pop) comes online and the lane flips: E in, Q twice, and burn her health bar before Condemn and stacked Silver Bolts are real threats. Adaptive Defenses appears once your own attack lands, so open the trade rather than waiting on it, and bait Condemn — 20s at rank 1, longer than your Hookshot.
Pooled Emerald+ win rates from Camille's side, sampled July 2026.
The full Camille vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Vayne, slightly — Camille wins 47.95% of 1,001 games; winnable with the right plan.
Mostly — Vayne has a small statistical edge (52.05% win rate), but execution decides this lane far more than the pick does.
No — if anything Vayne has the slight edge (Camille wins 47.95%), though it stays close.
Camille takes Conqueror on the Precision tree with Triumph, Legend: Alacrity and Last Stand, and Resolve secondary (Second Wind and Bone Plating) vs Vayne.
Start Doran's Shield + Health Potion (vs her poke) and back for Sheen + boots (≈1300g) — Q-reset spike. Build Trinity Force (Sheen → lethal Q resets) first, then Black Cleaver / Sundered Sky, with Plated Steelcaps.
Playing the other side? Vayne vs Camille guide →
All Camille top lane matchups →
More Camille top lane matchups: vs Trundle · vs Tryndamere · vs Urgot · vs Vladimir · vs Volibear · vs Warwick