Neeko vs Seraphine — Support Matchup Guide

How to win lane as Neeko against Seraphine · 50.1% win rate over 2,409 Emerald+ games · Updated 2026-07-27

Verdict: Neeko is favoured — Neeko owns 4 of the 7 game windows to Seraphine's 1. Neeko wins 50.1% of games vs Seraphine in support (2,409 Emerald+ games analysed).

Favour timeline — who owns each window

StageFavouredWhy
Level 1NeekoLevel 1 favours you as your Q-E burst beats her single-Q poke.
Level 2NeekoLevel 2 favours you: your all-in spike punishes an immobile mage.
Level 3NeekoLevel 3 favours you as you keep out-bursting before her tools online.
Levels 4-5Even / skillLevels 4-5 is skill as her E charm and shields offset your pressure.
Level 6NeekoLevel 6 favours you because R Pop Blossom dives her before Encore.
First itemEven / skillFirst item is skill with both scaling and picks going either way.
Two+ itemsSeraphine2+ items favours Seraphine whose layered utility out-scales your burst.

Early game (levels 1–5)

Level 1-3 is yours: Neeko's Q-E burst out-trades a single Seraphine Q and she has no mobility, so punish every poke step and threaten the all-in on your spike.

Read the rest of this matchup

The full Neeko vs Seraphine report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Related guides

Playing the other side? Seraphine vs Neeko guide →
All Neeko support matchups →