The champions that counter Diana hardest in mid lane are Vex (48.03%), Lissandra (48.64%) and Ahri (48.66%) — those are Diana's own pooled win rates. The easiest matchups are Ryze (56.89%), Mel (56.38%) and LeBlanc (56.16%).
46 researched matchup guides for Diana in mid lane, most-played first. Win rates are Diana's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Diana vs Sylas | 49.71% | 10,200 | Even |
| Diana vs Katarina | 52.32% | 9,673 | Leans Diana |
| Diana vs Ahri | 48.66% | 9,450 | Leans Ahri |
| Diana vs Zed | 52.66% | 9,359 | Leans Diana |
| Diana vs Viktor | 51.64% | 8,892 | Leans Diana |
| Diana vs Yasuo | 49.67% | 7,687 | Even |
| Diana vs Syndra | 51.3% | 7,630 | Leans Diana |
| Diana vs Yone | 52.35% | 7,001 | Leans Diana |
| Diana vs Fizz | 52.99% | 6,352 | Leans Diana |
| Diana vs Malzahar | 52.61% | 5,955 | Leans Diana |
| Diana vs Galio | 49.18% | 5,790 | Leans Galio |
| Diana vs Lux | 52.8% | 5,718 | Leans Diana |
| Diana vs Lissandra | 48.64% | 5,621 | Leans Lissandra |
| Diana vs LeBlanc | 56.16% | 5,495 | Diana favoured |
| Diana vs Naafiri | 54.15% | 5,313 | Leans Diana |
| Diana vs Vladimir | 50.05% | 5,063 | Even |
| Diana vs Twisted Fate | 49.8% | 4,480 | Even |
| Diana vs Hwei | 50.93% | 4,384 | Leans Diana |
| Diana vs Xerath | 49.26% | 4,231 | Even |
| Diana vs Karma | 54.46% | 3,981 | Leans Diana |
| Diana vs Talon | 51.65% | 3,957 | Leans Diana |
| Diana vs Ekko | 51.88% | 3,830 | Leans Diana |
| Diana vs Akshan | 52.64% | 3,638 | Leans Diana |
| Diana vs Irelia | 51.72% | 3,596 | Leans Diana |
| Diana vs Akali | 53.89% | 3,292 | Leans Diana |
| Diana vs Vex | 48.03% | 3,121 | Leans Vex |
| Diana vs Veigar | 49.98% | 3,033 | Even |
| Diana vs Ryze | 56.89% | 2,774 | Diana favoured |
| Diana vs Mel | 56.38% | 2,719 | Diana favoured |
| Diana vs Zoe | 50.7% | 2,712 | Even |
| Diana vs Qiyana | 54.75% | 2,696 | Leans Diana |
| Diana vs Kassadin | 49.6% | 2,631 | Even |
| Diana vs Orianna | 54.29% | 2,582 | Leans Diana |
| Diana vs Aurora | 52.95% | 2,478 | Leans Diana |
| Diana vs Anivia | 53.34% | 2,323 | Leans Diana |
| Diana vs Pantheon | 54.33% | 2,067 | Leans Diana |
| Diana vs Brand | 53.9% | 2,026 | Leans Diana |
| Diana vs Annie | 53.76% | 1,864 | Leans Diana |
| Diana vs Swain | 54.89% | 1,860 | Leans Diana |
| Diana vs Ziggs | 50.09% | 1,715 | Even |
| Diana vs Cassiopeia | 52.97% | 1,331 | Leans Diana |
| Diana vs Aurelion Sol | 51.26% | 1,313 | Leans Diana |
| Diana vs Taliyah | 51.04% | 1,293 | Leans Diana |
| Diana vs Azir | 53.86% | 1,270 | Leans Diana |
| Diana vs Neeko | 51.39% | 1,080 | Leans Diana |
| Diana vs Locke | — | — | — |