How to win lane as Cassiopeia against Karma · 50.75% win rate (1,326 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
Her combo chunks, your stream kills — survive the rotation, then fang her down in the fifteen seconds she has nothing.
Track: Karma's W — Focused Resolve (12s cooldown). The root tether — break it with range or line of sight.
Read from Cassiopeia's seat: which stage windows this plan plays for against Karma.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Karma | Level 1 favors Karma since her Q has better range and mana efficiency for safe poke trades. |
| Level 2 | Karma | Level 2 still favors Karma as she can layer RQ's root for extra poke and lane pressure. |
| Level 3 | Even / skill | Level 3 is a skill matchup since Cassiopeia's poison-E combo starts catching up in raw trade damage if played correctly. |
| Levels 4-5 | Cassiopeia | Levels 4-5 swing to Cassiopeia as her all-in burst begins outpacing Karma's poke-only damage profile. |
| Level 6 | Cassiopeia | Level 6 favors Cassiopeia because her ultimate threatens a full stun-burst kill, while Karma's ultimate is purely defensive/utility. |
| First item | Cassiopeia | Cassiopeia's first item poison ramp decisively out-damages Karma's flat poke scaling. |
| Two+ items | Cassiopeia | Two items in, Cassiopeia's burst and DPS both exceed anything Karma's utility-focused kit can trade back. |
Karma out-ranges you 950 to 850 in the poke war at levels 1-2 with Inner Flame on a 9-second cooldown, so avoid trading Q for Q in neutral positions. Farm with Q only when she's used hers, and watch for Focused Resolve rooting you for a jungler gank on your immobile self. Don't waste Miasma early just to threaten trades — save it to punish her when she steps past minions to poke.
Pooled Emerald+ win rates from Cassiopeia's side, sampled July 2026.
The full Cassiopeia vs Karma report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Cassiopeia, slightly — a 50.75% win rate edge over 1,326 games; execution can flip it.
Mostly — Cassiopeia has a small statistical edge (50.75% win rate), but execution decides this lane far more than the pick does.
Not a hard counter — Cassiopeia has a slight edge (50.75% win rate), and play quality decides the rest.
Cassiopeia takes Conqueror on the Precision tree with Presence of Mind, Legend: Haste and Last Stand, and Sorcery secondary (Manaflow Band and Transcendence) vs Karma.
Start Doran's Ring + 2 Health Potions and back for Tear of the Goddess + Dark Seal (≈800g). Build Seraph's Embrace first, then Liandry's Torment, with No boots — passive move speed (slot goes to Mercury's-substitute MR if needed).
Playing the other side? Karma vs Cassiopeia guide →
All Cassiopeia mid lane matchups →
More Cassiopeia mid lane matchups: vs Galio · vs Hwei · vs Irelia · vs Kassadin · vs Katarina · vs LeBlanc
Also played in: Top Lane