The champions that counter Akali hardest in mid lane are Galio (44.35%), Lissandra (45.28%) and Twisted Fate (45.75%) — those are Akali's own pooled win rates. The easiest matchups are Cassiopeia (54.76%), Azir (54.07%) and Mel (53.88%).
46 researched matchup guides for Akali in mid lane, most-played first. Win rates are Akali's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Akali vs Sylas | 49.58% | 15,810 | Even |
| Akali vs Viktor | 51.42% | 14,195 | Leans Akali |
| Akali vs Yasuo | 50.36% | 13,259 | Even |
| Akali vs Yone | 52.07% | 12,229 | Leans Akali |
| Akali vs Zed | 48.33% | 11,099 | Leans Zed |
| Akali vs Ahri | 47.64% | 10,824 | Leans Ahri |
| Akali vs Katarina | 50.17% | 10,089 | Even |
| Akali vs Syndra | 47.37% | 9,100 | Leans Syndra |
| Akali vs Lissandra | 45.28% | 8,376 | Leans Lissandra |
| Akali vs Twisted Fate | 45.75% | 8,274 | Leans Twisted Fate |
| Akali vs Malzahar | 46.73% | 7,132 | Leans Malzahar |
| Akali vs Lux | 50.4% | 6,986 | Even |
| Akali vs Naafiri | 51.85% | 6,629 | Leans Akali |
| Akali vs Fizz | 49.86% | 6,314 | Even |
| Akali vs LeBlanc | 49.31% | 6,055 | Even |
| Akali vs Vladimir | 47.83% | 6,053 | Leans Vladimir |
| Akali vs Hwei | 50.68% | 5,377 | Even |
| Akali vs Talon | 49.81% | 5,190 | Even |
| Akali vs Xerath | 50.38% | 5,171 | Even |
| Akali vs Galio | 44.35% | 5,135 | Galio favoured |
| Akali vs Vex | 46.33% | 5,029 | Leans Vex |
| Akali vs Karma | 51.96% | 5,021 | Leans Akali |
| Akali vs Irelia | 51.62% | 4,998 | Leans Akali |
| Akali vs Ekko | 49.87% | 4,516 | Even |
| Akali vs Veigar | 46.46% | 4,470 | Leans Veigar |
| Akali vs Akshan | 49.37% | 4,122 | Even |
| Akali vs Ryze | 49.8% | 3,966 | Even |
| Akali vs Orianna | 53.1% | 3,885 | Leans Akali |
| Akali vs Qiyana | 48.72% | 3,752 | Leans Qiyana |
| Akali vs Pantheon | 49% | 3,384 | Leans Pantheon |
| Akali vs Zoe | 48.76% | 3,355 | Leans Zoe |
| Akali vs Aurora | 50.29% | 3,301 | Even |
| Akali vs Diana | 46.11% | 3,292 | Leans Diana |
| Akali vs Kassadin | 47.1% | 3,017 | Leans Kassadin |
| Akali vs Mel | 53.88% | 3,005 | Leans Akali |
| Akali vs Annie | 47.43% | 2,950 | Leans Annie |
| Akali vs Anivia | 49.6% | 2,593 | Even |
| Akali vs Brand | 53.1% | 2,482 | Leans Akali |
| Akali vs Ziggs | 49.86% | 2,435 | Even |
| Akali vs Swain | 52.01% | 2,332 | Leans Akali |
| Akali vs Azir | 54.07% | 1,683 | Leans Akali |
| Akali vs Aurelion Sol | 49.37% | 1,665 | Even |
| Akali vs Taliyah | 46.33% | 1,649 | Leans Taliyah |
| Akali vs Neeko | 53.23% | 1,546 | Leans Akali |
| Akali vs Cassiopeia | 54.76% | 1,428 | Leans Akali |
| Akali vs Locke | — | — | — |