The champions that counter Senna hardest in bot lane are Tristana (50.04%), Twitch (50.62%) and Jinx (51.14%) — those are Senna's own pooled win rates. The easiest matchups are Corki (57.53%), Ezreal (57.13%) and Lucian (55.99%).
29 researched matchup guides for Senna in bot lane, most-played first. Win rates are Senna's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Senna vs Caitlyn | 53.62% | 40,347 | Leans Senna |
| Senna vs Jhin | 54.14% | 40,241 | Leans Senna |
| Senna vs Ezreal | 57.13% | 36,714 | Senna favoured |
| Senna vs Kai'Sa | 54.27% | 30,389 | Leans Senna |
| Senna vs Jinx | 51.14% | 27,555 | Leans Senna |
| Senna vs Ashe | 52.75% | 23,280 | Leans Senna |
| Senna vs Tristana | 50.04% | 20,844 | Even |
| Senna vs Lucian | 55.99% | 19,362 | Senna favoured |
| Senna vs Seraphine | 51.67% | 16,735 | Leans Senna |
| Senna vs Aphelios | 52.23% | 15,826 | Leans Senna |
| Senna vs Miss Fortune | 53.23% | 15,437 | Leans Senna |
| Senna vs Smolder | 54.1% | 14,377 | Leans Senna |
| Senna vs Ziggs | 52.53% | 11,537 | Leans Senna |
| Senna vs Samira | 54.32% | 10,825 | Leans Senna |
| Senna vs Sivir | 54.12% | 10,650 | Leans Senna |
| Senna vs Twitch | 50.62% | 10,641 | Even |
| Senna vs Vayne | 54.01% | 9,708 | Leans Senna |
| Senna vs Draven | 55.98% | 9,217 | Senna favoured |
| Senna vs Zeri | 52.31% | 9,104 | Leans Senna |
| Senna vs Xayah | 53.66% | 6,668 | Leans Senna |
| Senna vs Varus | 54.3% | 6,568 | Leans Senna |
| Senna vs Veigar | 53.36% | 4,987 | Leans Senna |
| Senna vs Swain | 53.86% | 4,801 | Leans Senna |
| Senna vs Kalista | 53.43% | 4,741 | Leans Senna |
| Senna vs Kog'Maw | 51.62% | 3,778 | Leans Senna |
| Senna vs Nilah | 52.5% | 2,501 | Leans Senna |
| Senna vs Corki | 57.53% | 2,244 | Senna favoured |
| Senna vs Karthus | 55.73% | 2,234 | Senna favoured |
| Senna vs Heimerdinger | 51.77% | 1,777 | Leans Senna |