How to win lane as Kai'Sa against Vayne · 50.2% win rate over 11,001 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Kai'Sa | Level 1 is yours because Vayne has no ranged ability and can't out-trade your auto plus W setup. |
| Level 2 | Kai'Sa | Level 2 stays Kai'Sa: with W and E you mark and kite her while she still has no ranged answer. |
| Level 3 | Kai'Sa | Level 3 is yours as your full Q-W-E combo out-ranges her 550 auto and short tumble. |
| Levels 4-5 | Kai'Sa | Levels 4-5 favor you since ranks in E and Q let you win every extended poke before her Silver Bolts matter. |
| Level 6 | Kai'Sa | Level 6 is even because her Final Hour stealth and movement can flip an all-in if her support commits, matching your ult. |
| First item | Even / skill | First item is skill-even as both of you spike, but her BOTRK plus true damage narrows the gap to a coin-flip on execution. |
| Two+ items | Kai'Sa | 2+ items swings back to you because ranged onslaught and Evolved E let you kite and burst her from safety in teamfights. |
You own levels 1-2: Vayne has no ranged trade tool and identical auto range, so contest every CS and W-mark her the instant she steps into last-hit range. Her only tools are melee-adjacent, so a support that can poke lets you shove her off the wave.
The full Kai'Sa vs Vayne report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
Become a Founding Member — $1.99/month →🔒 Secure checkout · 💰 7-day money-back guarantee · ✋ Cancel anytime
Early Access price — $3.99/month for new members after launch.
Playing the other side? Vayne vs Kai'Sa guide →
All Kai'Sa bot lane (adc) matchups →