The champions that counter Kai'Sa hardest in bot lane are Nilah (42.13%), Kog'Maw (42.37%) and Senna (45.73%) — those are Kai'Sa's own pooled win rates. The easiest matchups are Ezreal (53.11%), Ziggs (51.32%) and Varus (51.19%).
29 researched matchup guides for Kai'Sa in bot lane, most-played first. Win rates are Kai'Sa's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Kai'Sa vs Ezreal | 53.11% | 82,025 | Leans Kai'Sa |
| Kai'Sa vs Jhin | 51.19% | 64,033 | Leans Kai'Sa |
| Kai'Sa vs Caitlyn | 49.76% | 54,812 | Even |
| Kai'Sa vs Jinx | 46.45% | 44,857 | Leans Jinx |
| Kai'Sa vs Lucian | 49.96% | 39,034 | Even |
| Kai'Sa vs Ashe | 47.45% | 33,628 | Leans Ashe |
| Kai'Sa vs Senna | 45.73% | 30,389 | Leans Senna |
| Kai'Sa vs Tristana | 48.44% | 28,332 | Leans Tristana |
| Kai'Sa vs Miss Fortune | 48.15% | 24,559 | Leans Miss Fortune |
| Kai'Sa vs Xayah | 46.22% | 23,240 | Leans Xayah |
| Kai'Sa vs Seraphine | 47.33% | 22,058 | Leans Seraphine |
| Kai'Sa vs Vayne | 48.47% | 21,709 | Leans Vayne |
| Kai'Sa vs Aphelios | 47.46% | 21,646 | Leans Aphelios |
| Kai'Sa vs Twitch | 50.3% | 18,894 | Even |
| Kai'Sa vs Smolder | 47.98% | 18,892 | Leans Smolder |
| Kai'Sa vs Samira | 46.43% | 18,654 | Leans Samira |
| Kai'Sa vs Sivir | 48.13% | 17,547 | Leans Sivir |
| Kai'Sa vs Zeri | 46.93% | 15,485 | Leans Zeri |
| Kai'Sa vs Ziggs | 51.32% | 14,235 | Leans Kai'Sa |
| Kai'Sa vs Draven | 47.13% | 12,809 | Leans Draven |
| Kai'Sa vs Varus | 51.19% | 10,775 | Leans Kai'Sa |
| Kai'Sa vs Kalista | 50.69% | 7,940 | Even |
| Kai'Sa vs Swain | 49.68% | 7,478 | Even |
| Kai'Sa vs Veigar | 47.53% | 7,267 | Leans Veigar |
| Kai'Sa vs Kog'Maw | 42.37% | 6,065 | Kog'Maw favoured |
| Kai'Sa vs Nilah | 42.13% | 5,378 | Nilah favoured |
| Kai'Sa vs Corki | 49.74% | 4,433 | Even |
| Kai'Sa vs Karthus | 46.44% | 3,204 | Leans Karthus |
| Kai'Sa vs Heimerdinger | 48.67% | 2,443 | Leans Heimerdinger |