The champions that counter Senna hardest in support are Thresh (50.59%), Sona (50.69%) and Seraphine (50.72%) — those are Senna's own pooled win rates. The easiest matchups are Braum (55.68%), Alistar (55.47%) and Renata Glasc (55.13%).
35 researched matchup guides for Senna in support, most-played first. Win rates are Senna's side, pooled Emerald+ games sampled July 2026.
| Matchup | Win rate | Games | Favour |
|---|---|---|---|
| Senna vs Thresh | 50.59% | 29,534 | Even |
| Senna vs Seraphine | 50.72% | 25,325 | Even |
| Senna vs Nautilus | 53.15% | 23,862 | Leans Senna |
| Senna vs Lulu | 53.13% | 19,752 | Leans Senna |
| Senna vs Nami | 53.16% | 18,367 | Leans Senna |
| Senna vs Karma | 53.5% | 16,288 | Leans Senna |
| Senna vs Leona | 51.46% | 16,233 | Leans Senna |
| Senna vs Lux | 52.25% | 15,987 | Leans Senna |
| Senna vs Pyke | 51.53% | 15,880 | Leans Senna |
| Senna vs Bard | 53.41% | 14,168 | Leans Senna |
| Senna vs Milio | 52.84% | 13,864 | Leans Senna |
| Senna vs Blitzcrank | 51.9% | 12,832 | Leans Senna |
| Senna vs Yuumi | 54.3% | 11,310 | Leans Senna |
| Senna vs Soraka | 52.88% | 10,753 | Leans Senna |
| Senna vs Xerath | 51.37% | 9,024 | Leans Senna |
| Senna vs Vel'Koz | 52.49% | 8,913 | Leans Senna |
| Senna vs Morgana | 52.46% | 8,569 | Leans Senna |
| Senna vs Braum | 55.68% | 8,309 | Senna favoured |
| Senna vs Janna | 51.4% | 7,813 | Leans Senna |
| Senna vs Alistar | 55.47% | 7,623 | Senna favoured |
| Senna vs Rell | 51.32% | 7,361 | Leans Senna |
| Senna vs Rakan | 53.88% | 7,176 | Leans Senna |
| Senna vs Sona | 50.69% | 7,128 | Even |
| Senna vs Zilean | 50.76% | 6,844 | Leans Senna |
| Senna vs Brand | 53.62% | 6,212 | Leans Senna |
| Senna vs Zyra | 52.27% | 6,048 | Leans Senna |
| Senna vs Swain | 55.1% | 5,933 | Senna favoured |
| Senna vs Tahm Kench | 54.83% | 5,457 | Leans Senna |
| Senna vs Hwei | 53.63% | 5,406 | Leans Senna |
| Senna vs Galio | 55.09% | 4,903 | Senna favoured |
| Senna vs Neeko | 52.63% | 4,100 | Leans Senna |
| Senna vs Poppy | 52.08% | 3,971 | Leans Senna |
| Senna vs Maokai | 52.51% | 3,548 | Leans Senna |
| Senna vs Taric | 50.77% | 2,588 | Leans Senna |
| Senna vs Renata Glasc | 55.13% | 2,311 | Senna favoured |