Kha'Zix vs Karthus — Jungle Matchup Guide

How to win the jungle race as Kha'Zix against Karthus · Matchup data reviewed on patch 26.15

Verdict: Kha'Zix's race plan controls 6 of the 7 windows — Kha'Zix holds the tempo advantage in this jungle matchup.

The jungle race — the windows in Kha'Zix's plan

Read from Kha'Zix's seat: the race windows this plan plays for against Karthus.

StageReadWhy
Level 1 ClearKha'Zix DominantIsolation-bonus Taste Their Fear chunks anyone who face-checks alone. Lay Waste melts camps at record pace, and before either of you has a second camp down that is not an answer. Take the level-1 crossing and make Karthus path away from the camps you want.
Level 2 SkirmishKha'Zix DominantVoid Spike's heal-poke wins the slow trade war at river entrances. There is no version of this Karthus wins right now — Wall of Pain slows cover their disengage, and that folds on the second camp. Show on their side of the river and take the second buff and the tempo that comes with it.
Level 3 RouteKha'Zix DominantIso Q damage at level 3 already deletes squishier junglers caught solo. Later in the game this bites, because isolated Lay Waste double-damage adds up fast if you stand in his Defile zone. But as the first scuttle timer lands none of it is online, so take the level-3 river fight and tax every camp Karthus concedes.
Levels 4-5 MacroKha'Zix Dominant — Keep FightingNothing about 4-5 helps Karthus here: he out-farms the map through 4-5 — Defile clears at a rate nobody matches and Requiem is coming, while you can take any duel you can reach. Invade on the clear-timer, not on a whim.
Level 6 BreakpointEvolution FavouredYour first evolution means isolated targets simply die — hunt the side brushes, while Requiem cashes their farm lead into cross-map kills. You win the breakpoint against Karthus, not the whole game — cash it on the first objective after both sides hit six.
First Item SpikeUmbral Glaive / Eclipse SpikeUmbral Glaive clears the wards that would spot your approach and Eclipse adds a two-hit burst plus a shield, so an Isolated Taste Their Fear (Q) into Leap (E) now deletes squishy targets outright. Camps fall fast enough to clear a full side and still arrive at a lane. Use the spike to hunt lone targets in river and side lanes rather than joining even teamfights. Karthus' first item is where Lay Waste stops chipping and starts taking a third of a health bar per cast.
2+ Items ScalingRespect Karthus Late — End EarlyYou do not want the late 1v1 here. He deals damage from anywhere and keeps dealing it dead — Death Defied buys the fight — so trade the map instead, and keep every fight a numbers fight.

Runes & build vs Karthus

Start
Scorchclaw Pup + Health Potion
First back
Serrated Dirk + Refillable Potion — isolation duels come online
First item
Umbral Glaive / Eclipse
Then
Edge of Night / Hubris
Boots
Ionian Boots of Lucidity
Runes
Dark Harvest (Domination): Sudden Impact, Grisly Mementos, Ultimate Hunter · Precision: Triumph, Legend: Alacrity · Shards: Adaptive Force, Adaptive Force, Health

How to beat Karthus as Kha'Zix: the first clear and pathing

Start your clear at the Blue Buff node to optimize early ability haste cycling across single-target nodes before executing a clean full clear path down into the scuttle crab. Karthus has the fastest clear in the game with Lay Waste and Defile, and he will always be a level ahead if left alone.

Hardest and easiest matchups for Kha'Zix in the jungle

Ranked by the race windows in Kha'Zix's plans — the jungle race carries no win-rate sample.

Hardest

Easiest

Read the rest of this matchup

The full Kha'Zix vs Karthus report continues with scuttle & dragon rules, invade windows and safety boundaries, the top-side objective fight, macro rotations and the win condition — plus the live enemy-jungle tracker that shows their start, clear and gank timers in game.

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Common questions

Who wins Kha'Zix vs Karthus in the jungle?

Kha'Zix's race plan controls 6 of the 7 windows — Kha'Zix holds the tempo advantage in this jungle matchup.

Is Kha'Zix vs Karthus a skill matchup?

Not exactly — Kha'Zix's race plan controls 6 of the 7 windows, so Karthus is playing catch-up and has to lean on the map.

What runes does Kha'Zix take vs Karthus?

Kha'Zix takes Dark Harvest on the Domination tree with Sudden Impact, Grisly Mementos and Ultimate Hunter, and Precision secondary (Triumph and Legend: Alacrity) vs Karthus.

What should Kha'Zix build vs Karthus?

Start Scorchclaw Pup + Health Potion and back for Serrated Dirk + Refillable Potion — isolation duels come online. Build Umbral Glaive / Eclipse first, then Edge of Night / Hubris, with Ionian Boots of Lucidity.

Related guides

Playing the other side? Karthus vs Kha'Zix guide →
All Kha'Zix jungle matchups →

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