How to win lane as Miss Fortune against Karthus · 51.95% win rate (1,588 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15
He zones the channel you want — chip with bounces, dodge the rotation, and R the cooldown silence.
Track: Karthus's R — Requiem (200–160s cooldown). The global execute — recall above the red line and track it from his level 6 on.
Read from Miss Fortune's seat: which stage windows this plan plays for against Karthus.
This is Miss Fortune's own plan; across 1,588 pooled games the lane is leaning Miss Fortune.
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Miss Fortune | At level 1 your burst combo out-trades an immobile, mana-hungry Karthus. |
| Level 2 | Miss Fortune | Level 2 stays yours as you punish his poke-and-farm playstyle. |
| Level 3 | Miss Fortune | At 3 your Double Up combo beats him straight-up with no self-peel on his side. |
| Levels 4-5 | Miss Fortune | Through levels 4-5 his zero mobility lets you walk him down on Wall of Pain cooldowns. |
| Level 6 | Even / skill | At 6 Requiem's global execute evens the phase - low-HP misplays let his ult punish you. |
| First item | Miss Fortune | At one item your Bullet Time burst re-establishes the edge on a squishy caster. |
| Two+ items | Miss Fortune | By two-plus items you still out-duel his defenseless frame up close. |
You beat bot-lane Karthus levels 1-2: he's an immobile caster who wants to farm and poke with Lay Waste, and your Love Tap plus Double Up out-trade him whenever he steps up. Punish his mana-hungry early game and zone him off CS while respecting his Wall of Pain slow. He has to stand still to cast, which is exactly what Double Up wants. Bounce it through the wave and let Love Tap fire on every walk-up he makes. His mana runs out first if you keep the lane pushed, so take the plate and let your support open once he can no longer clear.
Pooled Emerald+ win rates from Miss Fortune's side, sampled July 2026.
The full Miss Fortune vs Karthus report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Miss Fortune, slightly — a 51.95% win rate edge over 1,588 games; execution can flip it.
Mostly — Miss Fortune has a small statistical edge (51.95% win rate), but execution decides this lane far more than the pick does.
Not a hard counter — Miss Fortune has a slight edge (51.95% win rate), and play quality decides the rest.
Miss Fortune takes Press the Attack on the Precision tree with Triumph, Legend: Bloodline and Coup de Grace, and Sorcery secondary (Manaflow Band and Gathering Storm) vs Karthus.
Start Doran's Blade + Health Potion and back for Serrated Dirk / Pickaxe (≈1100g). Build Collector / ER first, then Infinity Edge, with Mercury's Treads.
Playing the other side? Karthus vs Miss Fortune guide →
All Miss Fortune bot lane matchups →
More Miss Fortune bot lane matchups: vs Jinx · vs Kai'Sa · vs Kalista · vs Kog'Maw · vs Lucian · vs Nilah