How to win lane as Miss Fortune against Karthus · 54.7% win rate over 1,084 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Miss Fortune | At level 1 your burst combo out-trades an immobile, mana-hungry Karthus. |
| Level 2 | Miss Fortune | Level 2 stays yours as you punish his poke-and-farm playstyle. |
| Level 3 | Miss Fortune | At 3 your Double Up combo beats him straight-up with no self-peel on his side. |
| Levels 4-5 | Miss Fortune | Through levels 4-5 his zero mobility lets you walk him down on Wall of Pain cooldowns. |
| Level 6 | Even / skill | At 6 Requiem's global execute evens the phase - low-HP misplays let his ult punish you. |
| First item | Miss Fortune | At one item your Bullet Time burst re-establishes the edge on a squishy caster. |
| Two+ items | Miss Fortune | By two-plus items you still out-duel his defenseless frame up close. |
You beat bot-lane Karthus levels 1-2: he's an immobile caster who wants to farm and poke with Lay Waste, and your Love Tap plus Double Up out-trade him whenever he steps up. Punish his mana-hungry early game and zone him off CS while respecting his Wall of Pain slow.
The full Miss Fortune vs Karthus report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Karthus vs Miss Fortune guide →
All Miss Fortune bot lane (adc) matchups →