How to win lane as Karthus against Miss Fortune · 53.97% win rate over 504 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Karthus | You out-CS her and dodge Double Up bounces she needs for early poke. |
| Level 2 | Karthus | Level 2 W slows her dashless kit so your Q burst lands cleanly. |
| Level 3 | Karthus | Level 3 E Defile out-pressures her single Double Up bounce. |
| Levels 4-5 | Karthus | Levels 4-5 your zone denies Strut stacks while she has no all-in threat. |
| Level 6 | Karthus | R Requiem out-ranges and can finish her stationary Bullet Time. |
| First item | Karthus | First-item Defile scaling traps a dashless MF in constant AoE. |
| Two+ items | Karthus | In 2+ item fights your zone and global ult beat her channelled ult from range. |
Levels 1-2 deny her Double Up by never standing behind a low minion she can bounce off, and out-CS her with ranged Q; she has no dash, so she can't punish your step-ups the way you punish hers.
The full Karthus vs Miss Fortune report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Miss Fortune vs Karthus guide →
All Karthus bot lane (adc) matchups →