Zac vs Cassiopeia — Top Lane Matchup Guide

How to win lane as Zac against Cassiopeia · 35.38% win rate (65 Emerald+ games, lolalytics, sampled July 2026) · Matchup data reviewed on patch 26.15

Verdict: Cassiopeia is favoured — Zac wins only 35.38% of 65 games, and Cassiopeia pressures 6 of the 7 stage windows in the plan below. Play it patient and win your windows.

At a glance

She kites you out — survive, then slingshot her on the Miasma cooldown and out-sustain on blobs.

Track: Cassiopeia's W — Miasma (24–16s cooldown). Grounds you — dashes and movement abilities are disabled inside it.

Do

  • E from fog when Miasma is down
  • Pick up every blob
  • Q-stretch the double-hit

Don't

  • E into her peel
  • Let her stomp blobs
  • Fight with passive down

Runes & build vs Cassiopeia

Start
Doran's Shield + Health Potion
First back
Core component + boots (≈1300g)
First item
Heartsteel (HP feeds everything)
Then
Spirit Visage / Thornmail
Boots
Mercury's Treads
Runes
Grasp of the Undying (Resolve): Demolish, Second Wind, Overgrowth · Precision: Triumph, Legend: Haste · Shards: Health Scaling, Adaptive Force, Magic Resist

Favour timeline — the windows in Zac's game plan

Read from Zac's seat: which stage windows this plan plays for against Cassiopeia.

StageFavouredWhy
Level 1CassiopeiaNoxious Blast is a flat 3.5s cooldown at every rank.
Level 2CassiopeiaTwin Fang only spikes on targets already poisoned.
Level 3CassiopeiaMiasma grounds you from 3 — 24s at rank 1, so bait it out.
Levels 4-5CassiopeiaThrough 4-5 her sustained DPS out-damages your HP regen.
Level 6CassiopeiaPetrifying Gaze stuns you only if you are facing her.
First itemCassiopeiaAt first item her poison DPS melts you before you reach her.
Two+ itemsZacWith 2+ items your tank pool eats her poison and E-R kills her.

How to beat Cassiopeia as Zac: the early game

Cassiopeia poisons you with Noxious Blast every 3.5s, then Twin Fang hits harder and heals her off anything already poisoned — so the counter is not being poisoned. Soak XP at range and never slingshot into Miasma.

Hardest and easiest matchups for Zac in top lane

Pooled Emerald+ win rates from Zac's side, sampled July 2026.

Hardest

Easiest

Read the rest of this matchup

The full Zac vs Cassiopeia report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.

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Common questions

Who wins Zac vs Cassiopeia in top lane?

Cassiopeia — Zac wins only 35.38% of 65 games, so Zac plays this as the disadvantaged side.

Is Zac vs Cassiopeia a skill matchup?

Not really — Cassiopeia holds a real statistical advantage (64.62% win rate), so Zac is the one working uphill.

Does Zac counter Cassiopeia?

No — Cassiopeia counters Zac (Zac wins only 35.38% of games). Play it as the disadvantaged side and lean on the windows in the plan.

What runes does Zac take vs Cassiopeia?

Zac takes Grasp of the Undying on the Resolve tree with Demolish, Second Wind and Overgrowth, and Precision secondary (Triumph and Legend: Haste) vs Cassiopeia.

What should Zac build vs Cassiopeia?

Start Doran's Shield + Health Potion and back for Core component + boots (≈1300g). Build Heartsteel (HP feeds everything) first, then Spirit Visage / Thornmail, with Mercury's Treads.

Related guides

Playing the other side? Cassiopeia vs Zac guide →
All Zac top lane matchups →

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