How to win lane as Nasus against Cassiopeia · 49.66% win rate over 294 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Even / skill | You're both weak at level 1 — she has Q poison but no W grounding ranked yet, so neither owns it; soak Q farm and set up. |
| Level 2 | Cassiopeia | Her Q+W poison poke out-trades you and you have no Wither yet — concede CS and heal it with Soul Eater lifesteal. |
| Level 3 | Cassiopeia | She owns the kite — grounding W cancels any gap-close and poison stacks faster than your sustain answers it. |
| Levels 4-5 | Cassiopeia | Levels 4-5 stay hers: she pokes and kites with no-boots move speed while you hoard stacks and survive. |
| Level 6 | Even / skill | Fury of the Sands plus Wither lets you survive or punish her all-in — neither fully owns it, so it's skill on the cooldowns. |
| First item | Nasus | Sheen/Iceborn plus Wither shuts off her kite — empowered Q and E armor-shred run her grounded body down. |
| Two+ items | Nasus | Infinite Q stacks and ult out-duel her squishy HP bar — just commit Wither before her R face-stun can peel you. |
Cassiopeia's poison (Q) plus her grounding W is the early game — she chip-pokes you off the wave before you have Wither to answer, so don't walk up for a Q stack you'll pay double for in poison damage. Last-hit with the tip of your Spirit Fire (E) and let Soul Eater lifesteal heal the poison ticks. You concede these levels — that's fine, you're a juggernaut, just don't die to a full poison rotation chasing a stack.
The full Nasus vs Cassiopeia report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Cassiopeia vs Nasus guide →
All Nasus top lane matchups →