How to win lane as Karthus against Ezreal · 55.03% win rate over 1,123 Emerald+ games · Updated 2026-07-27
| Stage | Favoured | Why |
|---|---|---|
| Level 1 | Ezreal | Ezreal favours L1 because Mystic Shot out-ranges your Q and refunds cooldown on hit. |
| Level 2 | Ezreal | Ezreal favours L2 because his poke plus Arcane Shift safety out-trade your immobile self. |
| Level 3 | Ezreal | Ezreal favours L3 because he pokes freely while you can't punish his blink safety. |
| Levels 4-5 | Karthus | You favour L4-5 because Defile flips the sustain and waveclear war back to you. |
| Level 6 | Karthus | You favour L6 because Requiem is a strong pick on a poke-Ezreal who's rarely full health. |
| First item | Karthus | You favour first item because Defile out-sustains his poke and lets you catch a used Arcane Shift. |
| Two+ items | Karthus | You favour 2+ items because your sustained AoE and R outscale his single-target skillshot DPS. |
Ezreal controls levels 1-3: Mystic Shot out-ranges your Q and refunds on hit while Arcane Shift keeps him safe, so farm with Lay Waste, dodge behind minions, and avoid getting chunked.
The full Karthus vs Ezreal report continues with the mid-game plan, the late-game and teamfight plan, every power spike to play around, and the win conditions for both sides — plus cooldown tracking and the live enemy-jungle tracker inside the app.
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Playing the other side? Ezreal vs Karthus guide →
All Karthus bot lane (adc) matchups →